Police said Theresa Gibson, 59, was last seen at her home on the 1700 block of Arlington Street.
Gibson is 5 feet 7 inches tall and weighs 160 pounds, police said.
She has a medium complexion, brown eyes, and brown hair, police said.
Gibson was wearing red pants and black boots, and was carrying a green bag, when she was last seen, according to police.
Police said she has schizophrenia and requires medication.
Anyone with any information on Gibson’s whereabouts is asked to contact the Central Detective Division at (215) 686-3093 or call 911